Many websites and blogs talk about short term altitude issues, but no one addresses long term altitude issues that can occur in SOME PEOPLE living at high altitude, especially if born at sea level. Well, here is an abstract from the study done through (NCBI)
AbstractHigh-altitude (HA) environments have adverse effects on the normal functioning body of people accustomed to living at low altitudes because of the change in barometric pressure which causes decrease in the amount of oxygen leading to hypobaric hypoxia. Sustained exposure to hypoxia has adverse effects on body weight, muscle structure and exercise capacity, mental functioning, and sleep quality.
(Note... Read Carefully) People born into high altitude (Andes people) will not have these effects like those who were born at low altitude!! These are LONG TERM Effects of living above 6000'!
Why We Chose Salinas and Not Loja/Vilcabamba or other Beach Town?
#1. Loja is still above 6000'.
We chose Salinas because Salinas has everything we need while smaller beach towns do not.
#2. We are not interested in living in the earthquake zone so please quit asking us to move to Manta or Bahia, thanks.
Note*** We wrote about the potential for earthquakes from Manta to Esmeraldas in early 2012 in our DIY Coastal Landing Guide; we seriously cautioned folks to not buy property or move to these areas because of the risks for earthquakes.
#3. Angie wants to be at warmer, sunnier and dryer climate. Salinas fits that bill to a tee.
LONG TERM High Altitude Insomnia
High Altitude Breathing Problems While Sleeping
Why I Had to Change My Diet to a Fat Soluble High Mineral
STUDY: LONG TERM High Altitude Insomnia and sleep pattern problems begin at 6000' (for some people
At altitude, the reduced oxygen content of the blood induces breathing instability, with periods of deep and rapid breathing alternating with central apnea. This breathing pattern is called high-altitude periodic breathing (PB). It occurs even in healthy persons at altitudes above 6000 ft. It may lead to sleep disturbances with frequent awakenings and a feeling of lack of air 
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